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Since the rate of death and disability following cooling to a target of 33.5☌ continues to be high, we wished to explore whether cooling to a greater depth would be beneficial. One or more temperatures < 32.0☌ were noted during the induction phase of cooling in 33 infants, 2 during both induction and maintenance and 8 additional infants during the maintenance phase of cooling.
Jean tyson child development study center trial#
In the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network trial of whole body hypothermia to a target esophageal temperature of 33.5☌ for 72 hours for neonatal HIE, decreases below target temperature were noted with intermittent recording of temperatures recorded among some neonates undergoing cooling using with a servo-controlled system ( 6). The temperature profile of term neonates with encephalopathy undergoing therapeutic hypothermia has not been evaluated in the context of the phases of hypothermia. Therapeutic hypothermia is currently characterized in the adult literature as consisting of three phases: induction, maintenance and rewarming ( 5). Therapeutic hypothermia has been shown to reduce death and disabilities among neonates with hypoxic-ischemic encephalopathy (HIE) ( 1– 3) and increase the number of survivors without neurodevelopmental disabilities ( 4).